India has lost sixteen one day games after posting 300 plus runs either in its first innings or second innings. The following table lists all such occasions. The latest one in the list is India’s 308 for 8 against Australia at Brisbane on 15.01.16

India losing the one day games after posting 300 plus runs
No	Team	Score	Overs	Inns	Res	Margin	BR	Oppn	Ground	Start Date
1	India	300/7	50.0	2	lost	02 runs		Srl	Col=RPS	17 Aug 1997
2	India	306	47.0	2	Lost	43 runs		NZl	Rajkot	05 Nov 1999
3	India	310	48.5	2	lost	10 runs		RSA	Nagpur	19 Mar 2000
4	India	317	48.4	2	lost	12 runs		Pak	Rawalpindi	16 Mar 2004
5	India	315/6	48.0	1	lost	03 wkts	0	Pak	Ahmedabad	12 Apr 2005
6	India	328	49.4	1	lost	07 runs		Pak	Peshawar	06 Feb 2006
7	India	309/5	50.0	1	lost	29 runs		Win	Kuala Lumpur	14 Sep 2006
8	India	321/9	50.0	1	lost	04 wkts	1	Pal	Mohali	08 Nov 2007
9	India	308/7	50.0	1	lost	08 wkts	27	Pak	Karachi	02 Jul 2008
10	India	347	49.4	2	lost	03 runs		Aus	Hyd-RGS	05 Nov 2009
11	India	301/7	50.0	1	lost	03 wkts	5	Srl	Nagpur	18 Dec 2009
12	India	304/6	50.0	1	lost	06 wkts	10	Eng	Cardiff	16 Sep 2011
13	India	316/9	50.0	2	lost	09 runs		Eng	Rajkot	11 Jan 2013
14	India	303/9	50.0	1	lost	04 wkts	3	Aus	Mohali	19 Oct 2013
15	India	309/3	50.0	1	lost	05 wkts	4	Aus	Perth	12 Jan 2016
16	India	308/8	50.0	1	lost	07 wkts	6	Aus	Brisbane	15 Jan 2016

There are ten occasions when India could not defend a target of 300 plus runs and six occasions when India could not chase the target. The following table lists all such occasions

India unable to defend a target of 300 plus runs
No	Team	Score	Overs	Inns	Res	Margin	BR	Oppn	Ground	Start Date
1	India	315/6	48.0	1	lost	03 wkts	0	Pak	Ahmedabad	12 Apr 2005
2	India	328	49.4	1	lost	07 runs		Pak	Peshawar	06 Feb 2006
3	India	309/5	50.0	1	lost	29 runs		Win	Kuala Lumpur	14 Sep 2006
4	India	321/9	50.0	1	lost	04 wkts	1	Pal	Mohali	08 Nov 2007
5	India	308/7	50.0	1	lost	08 wkts	27	Pak	Karachi	02 Jul 2008
6	India	301/7	50.0	1	lost	03 wkts	5	Srl	Nagpur	18 Dec 2009
7	India	304/6	50.0	1	lost	06 wkts	10	Eng	Cardiff	16 Sep 2011
8	India	303/9	50.0	1	lost	04 wkts	3	Aus	Mohali	19 Oct 2013
9	India	309/3	50.0	1	lost	05 wkts	4	Aus	Perth	12 Jan 2016
10	India	308/8	50.0	1	lost	07 wkts	6	Aus	Brisbane	15 Jan 2016
India unable to chase the target of 300 plus runs
No	Team	Score	Overs	Inns	Res	Margin	BR	Oppn	Ground	Start Date
1	India	300/7	50.0	2	lost	02 runs		Srl	Col=RPS	17 Aug 1997
2	India	306	47.0	2	Lost	43 runs		NZl	Rajkot	05 Nov 1999
3	India	310	48.5	2	lost	10 runs		RSA	Nagpur	19 Mar 2000
4	India	317	48.4	2	lost	12 runs		Pak	Rawalpindi	16 Mar 2004
5	India	347	49.4	2	lost	03 runs		Aus	Hyd-RGS	05 Nov 2009
6	India	316/9	50.0	2	lost	09 runs		Eng	Rajkot	11 Jan 2013

There are three occasions when India could not defend a target of 300 plus runs against Australia and one occasion when India failed to chase the target against Australia.  The following table lists all such occasions

India unable to defend a target of 300 plus runs against Australia
No	Team	Score	Overs	Inns	Res	Margin	BR	Oppn	Ground	Start Date
1	India	303/9	50.0	1	lost	04 wkts	3	Aus	Mohali	19 Oct 2013
2	India	309/3	50.0	1	lost	05 wkts	4	Aus	Perth	12 Jan 2016
3	India	308/8	50.0	1	lost	07 wkts	6	Aus	Brisbane	15 Jan 2016
India unable to chase the target of 300 plus runs against Australia
No	Team	Score	Overs	Inns	Res	Margin	BR	Oppn	Ground	Start Date
1	India	347	49.4	2	lost	03 runs		Aus	Hyd-RGS	05 Nov 2009

India has lost eight one day games after posting 300 plus runs either in its first innings or second innings on away grounds and on neutral ground The following table lists all such occasions. The latest one in the list is India’s 308 for 8 against Australia at Brisbane on 15.01.16

India losing the one day games after posting 300 plus runs on away grounds and neutral venues
No	Team	Score	Overs	Inns	Res	Margin	BR	Oppn	Ground	Start Date
1	India	300/7	50.0	2	lost	02 runs		Srl	Col-RPS	17 Aug 1997
2	India	317	48.4	2	lost	12 runs		Pak	Rawalpindi	16 Mar 2004
3	India	328	49.4	1	lost	07 runs		Pak	Peshawar	06 Feb 2006
4	India	309/5	50.0	1	lost	29 runs		Win	Kuala Lumpur	14 Sep 2006
4	India	308/7	50.0	1	lost	08 wkts	27	Pak	Karachi	02 Jul 2008
6	India	304/6	50.0	1	lost	06 wkts	10	Eng	Cardiff	16 Sep 2011
7	India	309/3	50.0	1	lost	05 wkts	4	Aus	Perth	12 Jan 2016
8	India	308/8	50.0	1	lost	07 wkts	6	Aus	Brisbane	15 Jan 2016